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dc.contributor.authorFemir-Gurtuna, Banu
dc.contributor.authorKurt, Elif
dc.contributor.authorUlasoglu-Yildiz, Cigdem
dc.contributor.authorBayram, Ali
dc.contributor.authorYildirim, Elif
dc.contributor.authorSoncu-Buyukiscan, Ezgi
dc.contributor.authorBilgic, Basar
dc.descriptionKURT, ELIF/0000-0003-1956-575X; Femir, Banu/0000-0003-3649-6063; Bilgic, Basar/0000-0001-6032-0856; Bayram, Ali/0000-0002-6588-3479; Yildirim, Elif/0000-0003-3445-9197; Ulasoglu-Yildiz, Cigdem/0000-0003-1849-0055; Soncu Buyukiscan, Ezgi/0000-0003-1305-0560en_US
dc.descriptionPubMed: 32334962en_US
dc.description.abstractMild Cognitive Impairment (MCI) is characterized by cognitive deficits that exceed age-related decline, but not interfering with daily living activities. Amnestic type of the disorder (aMCI) is known to have a high risk to progress to Alzheimer's Disease (AD), the most common type of dementia. Identification of very early structural changes in the brain related to the cognitive decline in MCI patients would further contribute to the understanding of the dementias. In the current study, we target to investigate whether the white-matter changes are related to structural changes, as well as the cognitive performance of MCI patients. Forty-nine MCI patients were classified as Early MCI (E-MCI, n = 24) and Late MCI (L-MCI, n = 25) due to their performance on The Free and Cued Selective Reminding Test (FCSRT). Age-Related White-Matter Changes (ARWMC) scale was used to evaluate the white-matter changes in the brain. Volumes of specific brain regions were calculated with the FreeSurfer program. Both group and correlation analyses were conducted to show if there was any association between white-matter hyperintensities (WMHs) and structural changes and cognitive performance. Our results indicate that, L-MCI patients had significantly more WMHs not in all but only in the frontal regions compared to E-MCI patients. Besides, ARWMC scores were not correlated with total hippocampal and white-matter volumes. It can be concluded that WMHs play an important role in MCI and cognitive functions are affected by white-matter changes of MCI patients, especially in the frontal regions. (C) 2020 Elsevier Ltd. All rights reserved.en_US
dc.description.sponsorshipTUBITAK ARDEB 1003 ProgramTurkiye Bilimsel ve Teknolojik Arastirma Kurumu (TUBITAK) [114E053]; Istanbul University Scientific Research Funds [53037, 1567/42362]; Bogazici University Scientific Research FundsBogazici University [10520]en_US
dc.description.sponsorshipThis work was supported by funds from TUBITAK ARDEB 1003 Program (Grant #: 114E053), Istanbul University Scientific Research Funds (Grant #s: 53037, 1567/42362) and Bogazici University Scientific Research Funds (Grant #: 10520).en_US
dc.publisherElsevier Sci Ltden_US
dc.subjectMild cognitive impairmenten_US
dc.subjectWhite-matter hyperintensitiesen_US
dc.subjectEpisodic memoryen_US
dc.titleWhite-matter changes in early and late stages of mild cognitive impairmenten_US
dc.contributor.departmentBeykoz Universitesi Sosyal Bilimler Fakultesien_US
dc.contributor.institutionauthorFemir-Gurtuna, Banu
dc.relation.journalJournal Of Clinical Neuroscienceen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US

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