WoS İndeksli Yayınlar Koleksiyonu

Permanent URI for this collectionhttps://acikerisim2.beykoz.edu.tr/handle/20.500.12879/2

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Alterations in Niban Gene Expression as a Response to Stress Conditions in 3t3-L1 Adipocytes
(Springer, 2020) Cevik, Mehtap; Gunduz, Meliha Koldemir; Deliorman, Gokce; Susleyici, Belgin
Adipocyte death is important in obesity development. Understanding and prevention of adipocyte deaths may be a molecular approach in the treatment. In the study, we aimed to understand role of Niban gene, which acts as an anti-apoptotic molecule as a response to stress conditions, in adipocytes. 3T3-L1 adipocytes were treated with different doses of linoleic acid, hydrogen peroxide and ethanol; and proliferation of the cells examined with real time monitoring iCELLingence system. Gene expression levels were measured by q-PCR. As a response to 24h 480 mu M linoleic acid treatment, Niban gene expression was found to be higher than control group (p = 0.008), whereas 24 h 90 mM ethanol treatment was determined to be lower than control group (p = 0.008). The highest value of Niban gene expression among H2O2 treatment groups was detected in 4h 600 mu M H2O2 in comparison to control group (p = 0.008). To understand role of Niban in adipogenesis, Niban gene expressions were compared between pre-adipocytes and advanced fat accumulated adipocytes and determined to be significantly different (p = 0.042). Our results suggest that Niban might be involved in stress response process in adipocytes. However, the exact molecular role of Niban needs to be investigated in further studies.
The Effects of Transportation Modes on Campus Use: A Case Study of a Suburban Campus
(Elsevier Science Bv, 2019) Gocer, Ozgur; Gocer, Kenan
Efficient Shared Path Protection Routing for Survivable Optical WDM Networks
(IEEE, 2019) Erkan, O. Feyza; Erkan, Onur
Sustainability of the service continuity provided in the optical wavelength division multiplexing (WDM) networks with dynamic traffic environment requires effective protection schemes in the connections. Various approaches have been introduced for path protection and wavelength assignment to ensure survivability in WDM networks. In this paper, we propose a two-step algorithm to designate dedicated-path and shared-path protection schemes. The heuristic-based algorithm utilizes a global labeling which considers service time and line protection information. Thus, the algorithm aims to increase resource utilization by improving the efficiency of shared path protection. The proposed algorithm is applied to USNET and EuropeNet networks and performance analysis in terms of blocking probability and resource utilization is carried out.
Introduction of a Spatio-Temporal Mapping Based POE Method for Outdoor Spaces: Suburban University Campus as a Case Study
(Pergamon-Elsevier Science Ltd, 2018) Gocer, Ozgur; Gocer, Kenan; Basol, Altug M.; Kirac, M. Furkan; Ozbil, Ayse; Bakovic, Mujesira; Ozcan, Baris
Outdoor spaces are important to sustainable cities because they establish a common identity for social life by improving quality of urban living. The relation between outdoor spaces and building groups, competency, use period, and interaction of micro-climatic factors are needed to be investigated from a holistic approach. Unfortunately, the limited and narrow scoped POE studies on outdoor spaces make an overall assessment without causality relation. Other existing studies in outdoor spaces are mostly grouped under the headings such as; user satisfaction, space syntax and behavioral mapping, and biometeorological assessments. The intention of this paper is to introduce a new post-occupancy evaluation (POE) method integrates these studies focusing on various problems in outdoor spaces using spatio-temporal mapping. The comprehensive methodology applied in this research attempted to overcome some of the shortcomings of related studies by conducting a longitudinal study (during a year, as opposed to a few days) and also by objectively analyzing the associations of user behavior and physical attributes as well as the configurational properties of the campus layout. With this method, outdoor spaces can be evaluated in the context of the interaction between the physical environment and its users' behavior and activities, level of satisfaction and perceptions of comfort. The method has been applied on a suburban university campus in Istanbul, Turkey. The main courtyard of the campus has been subjected for map creation and result discussions.
The Marketization of Higher Education in Turkey (2002-2011)
(Palgrave, 2012) Onal, Nevzat Evrim

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