Scopus İndeksli Yayınlar Koleksiyonu

Permanent URI for this collectionhttps://acikerisim2.beykoz.edu.tr/handle/20.500.12879/3

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AI-Powered Digital Solutions in Food Safety: The GastroBlue Example
(Walter de Gruyter GmbH, 2026) Özkul, Emrah; Karacabey, Selda Uca; Demiral, Yaşar Mert; Karahan, Selda
Attenuated Rightward Hemispheric Asymmetry in ADHD: Structural MRI Evidence from a Normalized Asymmetry Index and Its Association with Cognitive Performance
(Frontiers Media SA, 2026) Tarlaci, Sultan; Cinaroglu, Metin; Yilmazer, Eda; Ulker, Selami Varol
Background Altered hemispheric asymmetry has been proposed as a potential neurodevelopmental feature of Attention-Deficit/Hyperactivity Disorder (ADHD). However, findings remain inconsistent, and the functional relevance of structural asymmetry patterns is not well established. This study examines volumetric and cortical-thickness asymmetries across cortical and subcortical regions in children and adolescents with ADHD compared to typically developing controls and evaluates their association with objective cognitive performance. Methods Forty participants with ADHD and 30 age- and sex-matched controls underwent high-resolution T1-weighted MRI. Bilateral regional volumes and cortical thickness were quantified using the volBrain pipeline, and asymmetry indices (AI = [R-L]/[(R + L)/2]) were computed for lobar and subcortical structures. Group differences were assessed using independent t-tests. Within the ADHD group, associations between asymmetry indices and MOXO-d-CPT performance (Attention, Timing, Impulsivity, Hyperactivity) were examined using Pearson correlations with correction for multiple comparisons. Results ADHD participants showed significantly reduced rightward asymmetry in frontal lobe volume, cerebellar hemispheres, caudate, putamen, and amygdala (ps < 0.05). Cortical-thickness asymmetry was also diminished in the frontal and parietal lobes and the anterior cingulate cortex. Temporal and occipital asymmetries were preserved. Within the ADHD group, greater rightward frontal and ACC thickness asymmetry correlated with better attention performance (r = 0.45 and 0.40), rightward parietal asymmetry associated with more accurate timing (r = 0.38), reduced rightward IFG asymmetry related to greater impulsivity (r = -0.42), and amygdala asymmetry correlated with lower hyperactivity (r = 0.36). Conclusion Children with ADHD exhibit a consistent attenuation of typical right-hemisphere dominance across frontal, striatal, cerebellar, and limbic systems. These altered asymmetry patterns are meaningfully associated with attentional control, timing accuracy, impulsivity, and hyperactivity, suggesting that hemispheric imbalance may serve as a structural may represent a neurodevelopmental characteristic associated with ADHD. Findings support models emphasizing right-hemisphere developmental lag and highlight hemispheric asymmetry as a clinically relevant dimension of ADHD neurobiology.
Cognitive Behavioral Therapy Reduces Symptom Severity and Normalizes Neurophysiological and Attentional Reactivity in Anorexia Nervosa: A Randomized Controlled Trial
(MDPI, 2026) Yılmazer, Eda; Çınaroğlu, Metin; Hızlı Sayar, Gökben; Ülker, Selami Varol
Background: Anorexia nervosa (AN) is a severe psychiatric disorder marked by restrictive eating, distorted body image, and high relapse rates. While cognitive-behavioral therapy (CBT) is a widely used treatment, its mechanisms of action in AN remain incompletely understood, particularly beyond self-reported symptom change. This study investigated the effects of a 12-week CBT intervention on both clinical and multimodal laboratory-based outcomes in women with restrictive-type AN. Methods: In a two-arm, pre-post randomized controlled trial (ClinicalTrials.gov: NCT07037017), 59 women with restrictive-type AN were randomized to a CBT intervention (n = 30) or no-treatment control (n = 29). A total of 50 participants (CBT: 26; control: 24) completed baseline and post-intervention assessments and were included in analyses. Outcomes included psychometric measures (eating disorder symptoms, depression, anxiety, body image-related obsessive-compulsive symptoms, and cognitive emotion regulation) and laboratory-based indices: electroencephalography (EEG), galvanic skin response (GSR), and eye-tracking during exposure to food- and body-related stimuli. Group & times; Time effects were analyzed using repeated-measures mixed-effects models, and statistical analyses were conducted using SPSS (Version 31; IBM Corp., Armonk, NY, USA). Results: Significant Group & times; Time interactions indicated greater improvements in the CBT group across all psychometric outcomes, including reduced eating disorder symptom severity (p < 0.001, eta(2)(p) = 0.28) and increased adaptive emotion regulation. CBT participants also showed significant reductions in EEG P300 and late positive potential (LPP) amplitudes to body-related stimuli, increased frontal alpha asymmetry, decreased visual fixation on salient body and food cues, and attenuated GSR reactivity (all p < 0.05). Exploratory correlations revealed that symptom improvements were associated with reductions in neurophysiological and attentional reactivity. Conclusions: To our knowledge, this is the first RCT in AN to demonstrate that CBT not only improves self-reported outcomes but also modulates neurophysiological and attentional processes implicated in the maintenance of the disorder. Multimodal laboratory assessments provided mechanistic insight into treatment effects and may inform personalized intervention strategies. CBT appears to facilitate recovery through both cognitive-emotional and physiological recalibration.
Ericksonian Hypnotherapy versus Cognitive Behavioral Therapy for Post-Traumatic Stress Disorder
(Routledge Journals, Taylor & Francis Ltd, 2026) Çınaroğlu, Metin; Yılmazer, Eda; Noyan Ahlatcıoğlu, Esra; Hızlı Sayar, Gökben; Ülker, Selami Varol
Post-traumatic stress disorder (PTSD) is characterized by persistent psychological distress and heightened neurophysiological reactivity. While trauma-focused cognitive behavioral therapy (CBT) is an established treatment, Ericksonian Hypnotherapy (EH) may offer comparable benefits via different therapeutic mechanisms. In this randomized clinical trial, 63 adults meeting DSM-5 criteria for PTSD were allocated (1:1:1) to EH, CBT, or a waitlist control; 54 participants completed post-treatment assessments. Both active interventions consisted of 12 weekly individual sessions. Outcomes included PTSD symptom severity (PCL-5), depression (BDI-II), anxiety (BAI), EEG markers (N2, P3, frontal alpha asymmetry), and autonomic reactivity (galvanic skin response, heart rate). Group & times; Time effects were analyzed using mixed-effects models. Treatment fidelity was independently evaluated. Both EH and CBT produced large and significant reductions in PTSD symptoms compared with waitlist, with no significant difference between the two therapies in total PCL-5 improvement. Depression and anxiety symptoms also decreased substantially in both active groups. Subscale analyses suggested slightly greater reductions in intrusion, hyperarousal, and somatic anxiety symptoms in EH, whereas CBT showed modestly greater improvement in cognitive depressive symptoms. Neurophysiological findings demonstrated parallel treatment-related changes across therapies, including normalization of ERP components, shifts toward left-frontal alpha activity, and reduced autonomic reactivity to trauma cues. No adverse events were observed. In this study, Ericksonian Hypnotherapy was as effective as trauma-focused CBT for reducing PTSD symptoms and associated psychological and physiological dysregulation, supporting EH as a viable alternative intervention for PTSD.
Preface
(IGI Global, 2024) Seçmen, Emre Ahmet
undefinedEvery Time We Walk, It Is a Pride March!undefined A Conversation on the Everyday Politics of Queer Walking
(Routledge Journals, Taylor & Francis Ltd, 2025) Avşar, Erdem; Akıncı, Özgül
This is a critical-meditative conversation between artist-researchers Avşar and Akıncı. Reflecting on 'queer walking' in two cities, Istanbul and Glasgow, it takes walking as an ever-shifting and embodied site of everyday politics. Avşar and Akıncı draw on voice messages, letters, and texts exchanged between them to auto-ethnographically trace how their daily walks have been undulating with wider political pressures and more intimate contexts. Echoing the Istanbul pride slogan, 'Every time we walk, it is a pride march!', this dialogue insists on honouring the quiet political capacities of walking queerly without overlooking the vulnerabilities that such public mobility can carry in autocratic regimes.

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