PubMed İndeksli Yayınlar Koleksiyonu

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Binary Particle Swarm Optimization as a Detection Tool for Influential Subsets in Linear Regression
(Taylor & Francis Ltd, 2021) Deliorman, G.; Inan, D.
An influential observation is any point that has a huge effect on the coefficients of a regression line fitting the data. The presence of such observations in the data set reduces the sensitivity and validity of the statistical analysis. In the literature there are many methods used for identifying influential observations. However, many of those methods are highly influenced by masking and swamping effects and require distributional assumptions. Especially in the presence of influential subsets most of these methods are insufficient to detect these observations. This study aims to develop a new diagnostic tool for identifying influential observations using the meta-heuristic binary particle swarm optimization algorithm. This proposed approach does not require any distributional assumptions and also not affected by masking and swamping effects as the known methods. The performance of the proposed method is analyzed via simulations and real data set applications.
Cognitive Behavioral Therapy for Muscle Dysmorphia and Anabolic Steroid-Related Psychopathology: A Randomized Controlled Trial
(MDPI, 2025) Cinaroglu, Metin; Yilmazer, Eda; Ulker, Selami Varol; Sayar, Gokben Hizli
Background/Objectives: Muscle dysmorphia (MD), a subtype of body dysmorphic disorder, is prevalent among males who engage in the non-medical use of anabolic-androgenic steroids (AASs) and performance-enhancing drugs (PEDs). These individuals often experience severe psychopathology, including mood instability, compulsivity, and a distorted body image. Despite its clinical severity, no randomized controlled trials (RCTs) have evaluated structured psychological treatments in this subgroup. This study aimed to assess the efficacy of a manualized cognitive behavioral therapy (CBT) protocol in reducing MD symptoms and associated psychological distress among male steroid users. Results: Participants in the CBT group showed significant reductions in MD symptoms from the baseline to post-treatment (MDDI: p < 0.001, d = 1.12), with gains sustained at follow-up. Large effect sizes were also observed in secondary outcomes including depressive symptoms (PHQ-9: d = 0.98), psychological distress (K10: d = 0.93), disordered eating (EDE-Q: d = 0.74), and exercise addiction (EAI: d = 1.07). No significant changes were observed in the control group. Significant group x time interactions were found for all outcomes (all p < 0.01), indicating CBT's specific efficacy. Discussion: This study provides the first RCT evidence that CBT significantly reduces both core MD symptoms and steroid-related psychopathology in men engaged in AAS/PED misuse. Improvements extended to mood, body image perception, and compulsive exercise behaviors. These findings support CBT's transdiagnostic applicability in addressing both the cognitive-behavioral and affective dimensions of MD. Materials and Methods: In this parallel-group, open-label RCT, 59 male gym-goers with DSM-5-TR diagnoses of MD and a history of AAS/PED use were randomized to either a 12-week CBT intervention (n = 30) or a waitlist control group (n = 29). CBT sessions were delivered weekly online and targeted distorted muscularity beliefs, compulsive behaviors, and emotional dysregulation. Primary and secondary outcomes-Muscle Dysmorphic Disorder Inventory (MDDI), PHQ-9, K10, EDE-Q, EAI, and BIG-were assessed at the baseline, post-treatment, and 3-month follow-up. A repeated-measures ANOVA and paired t-tests were used to analyze time x group interactions. Conclusions: CBT offers an effective, scalable intervention for individuals with muscle dysmorphia complicated by anabolic steroid use. It promotes broad psychological improvement and may serve as a first-line treatment option in high-risk male fitness populations. Future studies should examine long-term outcomes and investigate implementation in diverse clinical and cultural contexts.
Comparing Cognitive Behavioral Therapy and Ericksonian Hypnotherapy for Subclinical Depression and Anxiety: A Randomized Controlled Trial
(Routledge Journals, Taylor & Francis Ltd, 2025) Cinaroglu, Metin; Yilmazer, Eda; Odabasi, Cemre; Ulker, Selami Varol; Sayar, Gokben Hizli
This randomized controlled trial examined the effectiveness of Cognitive Behavioral Therapy (CBT) and Ericksonian Hypnotherapy (EH) in reducing symptoms of depression and anxiety among individuals with subclinical levels of distress. A total of 150 participants were screened, and 45 eligible participants were randomized into three groups: CBT (n = 15), EH (n = 15), and a waitlist control group (n = 15). Interventions consisted of 12 weekly sessions, with assessments conducted at baseline, mid-intervention, and post-intervention using the Beck Depression Inventory-II (BDI-II) and Beck Anxiety Inventory (BAI). Both CBT and EH significantly reduced symptoms of depression and anxiety compared to the control group, with no significant differences in efficacy between the two interventions. CBT's structured approach demonstrated consistent improvements across both depression and anxiety, while EH showed a slightly faster reduction in anxiety symptoms at mid-intervention, highlighting its potential for addressing somatic and cognitive dimensions of anxiety. This study extends previous findings by focusing on a non-clinical population, emphasizing the potential of these interventions as early strategies for preventing symptom escalation. Unlike prior work primarily targeting diagnosed populations, this research underscores the applicability of CBT and EH in addressing subthreshold distress. Limitations include a small sample size, lack of follow-up assessments, and reliance on self-reported measures. Future research should explore long-term outcomes, larger samples, and the integration of CBT and EH. These findings contribute to the growing body of evidence supporting diverse psychotherapeutic modalities for early mental health intervention.
Comparison of Domino Transplantation with Two-Way Paired Exchange and Normal Transplantation: Acute Rejection, Surgical Complications, and 5-Year Survival Outcomes
(Springer, 2025) Huseynov, Amil; Cicek, Sevim Nuran Kuslu
Background Domino kidney paired donation and Two-Way Paired Exchange have emerged as vital strategies to expand the donor pool in renal transplantation, especially for patients facing ABO or HLA incompatibilities. Despite their potential benefits, concerns remain regarding immunological risks, infectious complications, and long-term graft survival. Methods In this retrospective cohort study conducted at Medicana Transplant Center, 980 adult kidney transplant recipients were categorized into three groups: Domino (n = 144), Two-Way Paired Exchange (n = 350), and Normal Transplant (n = 486). Baseline characteristics, acute rejection rates, and surgical or infectious complications were collected, alongside data on 1-year and 5-year patient and graft survival. Statistical analysis included Kaplan-Meier survival curves and Cox proportional hazards modeling for independent predictors of graft outcomes. Results The Domino group had the highest 1-year acute rejection rate (17.4%) compared to Two-Way Paired Exchange (4.3%) and Normal Transplant (3.7%), yet 1-year graft survival rates remained comparable (92%, 95%, and 96%, respectively; p = 0.271). Infectious complications were more frequent in the Domino group (25%) than in others (p < 0.01). Extended follow-up to 5 years indicated no statistically significant difference in overall graft or patient survival among the three groups (log-rank p = 0.197), despite a trend toward lower 5-year graft survival in the Domino group. Donor-specific antibodies and higher HLA mismatches independently predicted acute rejection. Conclusions Domino transplantation, while associated with higher immunologic challenges, achieves acceptable short-term and 5-year outcomes akin to Two-Way Paired Exchange and Normal Transplant. Careful immunosuppressive strategies, vigilant monitoring, and collaborative protocols are integral for optimizing long-term success in high-risk transplant scenarios.
Effect of Multi-Artery Renal Grafts on Patient Outcomes in Living Donor Kidney Transplantation
(Springer, 2025) Huseynov, Amil; Sengul, Halil
BackgroundMultiple renal arteries (MRA) in a donor kidney can increase surgical complexity in living donor kidney transplantation. However, the impact of MRA on early transplant outcomes, including delayed graft function (DGF) and early graft failure, remains unclear.MethodsWe performed a single-center retrospective cohort study of 1,200 living donor kidney transplants conducted between 2019 and 2024. Donor kidneys were classified as having a single renal artery or multiple renal arteries (two or more). Recipient and donor characteristics, intraoperative details (ischemia times, vascular anastomosis technique), and postoperative outcomes (delayed graft function [DGF], primary nonfunction, and graft survival) were compared between the two groups. Logistic regression analyses were used to examine associations between MRA and the risk of DGF or graft failure within the first 90 days, both before and after adjusting for prespecified covariates.ResultsOf the 1,200 transplanted kidneys, 882 (73.5%) had a single artery and 318 (26.5%) had multiple arteries. Although the median cold-ischemia time was longer for multi-artery grafts (35.2 min vs. 29.4 min, p = 0.004), there were no significant differences in donor or recipient baseline characteristics. Multivariable logistic regression revealed no significant association between MRA and either DGF or early graft loss. Kaplan-Meier curves, censored for death, demonstrated similar graft survival in both groups (log-rank p = 0.25).ConclusionsIn this single-center cohort of living donor kidney transplants, grafts with multiple renal arteries did not exhibit an elevated risk of DGF or early graft loss. While additional surgical complexity is often required for MRA grafts, our findings suggest that these kidneys remain a safe and effective option for transplantation, supporting their broader use to expand the donor pool.
Effects of Ericksonian Hypnotherapy Versus Cognitive Behavioral Therapy on Prolonged Grief Among University Students: A Randomized Clinical Trial
(Routledge Journals, Taylor & Francis Ltd, 2025) Cinaroglu, Metin; Yilmazer, Eda; Ulker, Selami Varol; Cinar, Fadime
This study evaluates the comparative effectiveness of Ericksonian Hypnotherapy (EH) and Cognitive Behavioral Therapy (CBT) in addressing prolonged grief among university students in Istanbul. Transitioning through critical developmental phases, 39 students who had experienced significant loss and demonstrated symptoms of prolonged grief participated in this randomized controlled trial. They were divided equally into three groups: those receiving EH, those undergoing CBT, and a control group placed on a waiting list. Assessments utilized the Prolonged Grief Scale and the Beck Depression Inventory to measure the interventions' impact on grief. Findings revealed significant improvements in both EH and CBT groups compared to the control, with EH showing marginally higher effectiveness in reducing grief symptoms. This research underlines EH's potential as a culturally adaptable and effective treatment for prolonged grief in a diverse academic setting, advocating for its broader application and further exploration across various populations.
Ethical Leadership and Perceived Organizational Fairness: A Moderated Mediation Model of Moral Identity and Psychological Contract Breach
(Routledge Journals, Taylor & Francis Ltd, 2025) Aktas, Burak Nedim; Gunalan, Mustafa; Akcin, Kultigin; Erat, Serhat
This study identifies when and how ethical leadership is linked to employees' perceptions of organizational fairness. We propose and test a mechanism in which followers' moral identity explains this link, and the state of the psychological contract sets its boundaries, highlighting a novel, process-focused view of fairness formation. Using a cross-sectional survey of 306 white-collar employees in T & uuml;rkiye's industrial sector, we estimated a moderated-mediation model with partial least squares structural equation modeling and bootstrap inference. Results revealed that ethical leadership related to perceived organizational fairness indirectly through the symbolization (outward expression) facet of moral identity, whereas internalization (inward conviction) was unrelated. This indirect link emerged only when employees perceived that promised obligations were honored, indicating that psychological-contract fulfillment enables ethical signals to be read as fair. The findings clarify that visible moral behavior matters more than inward conviction for fairness judgments and that relational integrity is a precondition for leader influence. We discuss implications for theory and for building fair climates by making ethics visible and keeping promises.
Interhemispheric EEG Coherence as a Candidate Biomarker in Gambling Disorder: Evidence of Frontal Hyperconnectivity and Posterior Disconnectivity
(Frontiers Media SA, 2025) Yilmazer, Eda; Cinaroglu, Metin; Ulker, Selami Varol; Tarlaci, Sultan
Background Gambling Disorder (GD) is a behavioral addiction marked by impaired decision-making and poor impulse control. We investigated whether resting-state interhemispheric quantitative EEG (qEEG) coherence-a measure of functional connectivity between homologous cortical regions-could serve as a biomarker of GD.Methods Twenty-nine male patients with GD and 45 healthy male controls underwent resting-state qEEG recording. Coherence was computed for homologous electrode pairs across delta, theta, alpha, and beta bands. Group differences were analyzed using independent-samples t-tests; associations with disorder duration were assessed via age-controlled partial correlations.Results Consistent with our hypothesis, GD participants exhibited frontal pole hypercoherence (Fp1-Fp2) across delta, theta, and beta bands, which is likely influenced by prefrontal/orbitofrontal generators. In contrast, GD showed hypocoherence in temporal (T3-T4, T5-T6), central (C3-C4), and parietal (P3-P4) regions across these frequencies. Greater disorder duration was associated with lower beta coherence at F3-F4 and Fp1-Fp2, and higher delta coherence at O1-O2.Conclusions These findings reveal a dual pattern of interhemispheric connectivity disruption in GD-hypercoherence at frontal pole sites and hypocoherence in sensorimotor and attentional posterior networks-supporting theoretical models of addiction neurocircuitry. Resting-state qEEG coherence holds promise as a clinically relevant biomarker for GD and may inform the development of neuromodulatory interventions aimed at network rebalancing.
The Mediating Role of Cognitive Emotion Regulation Skills in the Relationship Between Romantic Relationship Satisfaction and Eating Attitudes
(Springer Nature, 2025) Yilmazer, Eda; Turk, Fulya; Hamamci, Zeynep
Background Romantic relationship satisfaction has been linked to psychological outcomes, including emotional well-being and eating behaviors. However, the mechanisms underlying this relationship remain unclear. This study examines the mediating role of cognitive emotion regulation strategies-particularly catastrophizing-in the relationship between romantic relationship satisfaction and eating attitudes. Methods A cross-sectional study was conducted with 355 university students. Participants completed the Relationship Satisfaction Scale, the Cognitive Emotion Regulation Questionnaire (CERQ), and the Eating Attitudes Test-26 (EAT-26). Structural equation modeling (SEM) was performed using AMOS and R with robust maximum likelihood estimation. Model fit was evaluated using chi 2/df, CFI, GFI, RMSEA, and SRMR. Results Catastrophizing significantly mediated the relationship between romantic relationship satisfaction and eating attitudes. Romantic relationship satisfaction was negatively associated with catastrophizing (beta = -0.18, p = .028), and catastrophizing was positively associated with problematic eating attitudes (beta = 0.35, p < .001). The direct effect of romantic relationship satisfaction on eating attitudes was not statistically significant (beta = -0.12, p = .104), indicating full mediation. Acceptance did not significantly mediate the relationship (p = .348). Gender differences were observed: women scored significantly higher on rumination, dieting, and bulimia/food preoccupation (p < .05). Conclusions These findings highlight the role of maladaptive cognitive emotion regulation-specifically catastrophizing-in linking romantic relationship dissatisfaction with disordered eating attitudes. Targeting catastrophizing in interventions may improve both relationship satisfaction and eating behaviors.
Menstrual Cycle-Related Changes in Women with Schizophrenia: A Resting-State fMRI Study
(Karger, 2022) Noyan, Handan; Hamamci, Andac; Firat, Zeynep; Sarsilmaz, Aysegul; Ucok, Alp
Introduction: Different influences of ovarian hormones in schizophrenia (SCZ) have been reported, but no study to date has assessed their effects on the brain dynamics at rest. The present study aimed to examine the hormonal and clinical changes related to the menstrual cycle and alterations in the resting-state functional connectivity (RS-FC) depending on cycle phase and/or hormonal fluctuations in SCZ. Method: This study was conducted based on both between- and within-subject experimental designs, including 13 clinically stable female patients with SCZ (32 +/- 7.7 years) and 13 healthy women (30 +/- 7.3 years). RS-functional magnetic resonance imaging (fMRI) scanning, as well as hormonal and clinical assessments, was applied to each participant twice during two cycle phases: early follicular and mid-luteal. Results: A difference in mid-luteal progesterone levels was found between groups, with a large effect size (Cohen's d) of 0.8 (p < 0.05). Also, the estradiol levels negatively correlated with the negative symptom severity of the patients during their mid-luteal phase. In the patients, estrogen positively correlated with the auditory network connectivity in the left amygdala during the early follicular phase. In the controls, progesterone had positive correlations with the connectivity of the posterior default mode and the left frontoparietal networks in the bilateral precuneus during the early follicular phase and had a negative correlation with the executive control network connectivity in the mid-luteal phase. Conclusion: The present study showed hormonal differences between groups and suggested that the levels of cycle-dependent hormones might be associated with the changes in clinical symptom severity and the RS-FC in the groups. Our RS-fMRI findings warrant further investigation.
Of the Manuscript: Predictive Value of Renal Parenchyma and Pelvic Urine Density on Preoperative Non-Contrast CT in Systemic Inflammatory Response Syndrome (SIRS) After Semi-Rigid Ureteroscopy
(Springer, 2025) Ozsoy, Emrah; Kutluhan, Musab Ali; Tokuc, Emre; Kayar, Ridvan; Demir, Samet; Meric, Kaan; Ozturk, Metin Ishak
To evaluate the predictive value of preoperative NCCT (Non-Contrast Computed Tomography) measured renal parenchyma and pelvic urine densities for the development of systemic inflammatory response syndrome (SIRS) following URS. 1262 patients underwent semi-rigid URS due to ureterolithiasis between January 2008 and August 2023 were screened and 286 patients were included. Patient demographics and NCCT findings (stone size, location, density, hydronephrosis, renal parenchymal density, pelvic urine density) were collected retrospectively. Patients were categorized into two groups based on SIRS development after URS. Pelvic urine and parenchyma densities of the obstructed kidney were compared. A multivariate logistic regression analysis was performed to identify independent predictors of SIRS. The median obstructed kidney cortex mean density was significantly lower in the SIRS (+) group compared to the SIRS (-) group (26.67 [22.33-29.50] vs. 33.33 [27.24-37.75]). Obstructed kidney medulla mean density was also significantly lower in patients with SIRS (24.00 [22.33-27.50] vs. 31.50 [26.24-36.75], p = 0.001). Pelvic urine density was significantly higher in the SIRS-positive group. Stone density (OR = 1.35, % 95 CI: 1.09-1.67, p = 0.006), proximal ureteral location (OR = 5.21, % 95 CI: 1.84-14.7, p = 0.002), cortex mean density (OR = 0.91, % 95 CI: 0.87-0.95, p = 0.001) and pelvic urine density (OR = 1.07, % 95 CI: 1.02-1.12, p = 0.010) were stated as significant predictors. Renal parenchyma and pelvic urine density on pre-operative NCCT can predict SIRS after semi-rigid URS.
Predictive Impact of PI-RADS 3 Lesion Volume/Total Prostate Volume Ratio in Prostate Cancer Diagnosis in Biopsy-Naïve Patients Volume Ratio in Prostate Cancer Diagnosis in Biopsy-Naive Patients
(TÜBİTAK Scientific & Technological Research Council Turkey, 2025) Ozsoy, Emrah; Kutluhan, Musab Ali; Tokuc, Emre; Kayar, Ridvan; Demir, Samet; Meric, Kaan; Ozturk, Metin Ishak
Background/aim: To assess the potential of the ratio between PI-RADS 3 lesion volume and total prostate volume as a predictive parameter for guiding the decision to perform a biopsy in patients presenting with PI-RADS 3 lesions on multiparametric prostate magnetic resonance imaging (mpMRI). Materials and methods: A total of 749 patients who underwent mpMRI due to suspected prostate cancer between January 2014 and August 2023 were scanned. Based on predefined inclusion and exclusion criteria, 308 patients were included. Age, total prostate-specific antigen (PSA) value, prostate volume measured in mpMRI, mpMRI result, PI-RADS 3 lesion volume, and biopsy results were collected. The PI-RADS 3 ratio was calculated as PI-RADS 3 lesion volume/total prostate volume. PSA density (dPSA) was calculated. The patients were categorized according to their biopsy results as benign or malignant (subclassified by Gleason group grade), and the two groups were compared. Results: The average PI-RADS 3 ratio was 0.032 +/- 0.002. There were 230 (74.7%) patients in the benign group and 78 (25.3%) patients in the malignant group. There was a statistically significant difference detected in average prostate volumes (p < 0.001), dPSA values (p = 0.001), and PI-RADS 3 ratios (p < 0.001). The receiver operating curve analysis of PI-RADS 3 ratio indicated an area under the curve of 0.643 +/- 0.037. The optimal cut-off point was 0.026 with a sensitivity of 58.97% and a specificity of 66.96%. A positive, albeit weak, statistically significant relationship was found between PIRADS-3 ratios and dPSA values (rs rho = 0.261 and p < 0.001). Conclusion: PI-RADS 3 ratio may serve as an auxiliary clinical parameter alongside age, dPSA, and lesion volume alone in identifying more refined candidates for biopsy in the goal of patient care individualization.
Predictive Value of Renal Parenchyma and Pelvic Urine Density on Preoperative Non-Contrast CT in Systemic Inflammatory Response Syndrome (SIRS) After Semi-Rigid Ureteroscopy (Vol 54, 15, 2025)
(Springer, 2026) Ozsoy, Emrah; Kutluhan, Musab Ali; Tokuc, Emre; Kayar, Ridvan; Demir, Samet; Meric, Kaan; Ozturk, Metin Ishak
Problematic Social Media Use, Self-Objectification, and Body Image Disturbance: The Moderating Roles of Physical Activity and Diet Intensity
(Dove Medical Press Ltd, 2025) Cinaroglu, Metin; Yilmazer, Eda
Purpose: This study examines the relationship between problematic social media use, self-objectification, and body image disturbance in women, with physical activity and diet intensity as moderators. It also explores the psychological outcomes of depression and anxiety.
Methods: A cross-sectional study was conducted with 594 women aged 18- 65 in Istanbul, T & uuml;rkiye. Participants completed validated measures assessing social media use, self-objectification, body image disturbance, physical activity, diet intensity, depression, and anxiety. A moderated mediation analysis was performed.
Results: Self-objectification significantly mediated the relationship between problematic social media use and body image disturbance (b = 0.14, SE = 0.03, 95% CI [0.10, 0.21], p < 0.01, R-2 = 0.18). Physical activity buffered this effect (b = - 0.12, SE = 0.05, p = 0.02, d = 0.36), while diet intensity exacerbated it (b = 0.15, SE = 0.04, p < 0.01, d = 0.42). Body image disturbance also mediated the association between social media use and depression (b = 0.18, SE = 0.05, p < 0.01, R-2 = 0.22) and anxiety (b = 0.16, SE = 0.04, p < 0.01, R-2 = 0.19).
Conclusion: The findings highlight the dual roles of physical activity and diet intensity in shaping body image outcomes. The study underscores the need for targeted interventions to mitigate the negative impact of social media-driven self-objectification on body image and mental health.
Regenerative Therapy Approaches and Encountered Problems in Sensorineural Hearing Loss
(Bentham Science Publ Ltd, 2023) Kelleci, Kuebra; Golebetmaz, Eda
Hearing loss is one of the most important public health matters worldwide, severely affecting people's social, psychological, and cognitive development. The perception of sound, movement, and balance in vertebrates depends on a special sensory organ called the cochlea, which contains hair cells and supporting cells in the inner ear. Genetic factors, epigenetics, the use of ototoxic drugs (some antibiotics and chemotherapeutics), noise, infections, or even aging can cause loss of hair cells and their related primary neurons, leading to sensorineural hearing loss. Although a sensorineural hearing loss, also known as permanent hearing loss, is treated with hearing aids and cochlear implants, treatment methods are limited. Since even the best implant cannot exhibit the characteristics of the original ear, the permanent sensory deficit will be permanent. For this reason, it has become important to develop regenerative treatment methods to regenerate and replace lost or damaged hair cells and neurons. Developments in stem cell technology have led to promising studies in regenerating damaged/lost hair cells or neurons with endogenous or exogenous cell-based therapies. Epigenetic mechanisms can turn hearing-related genes on and off and determine which proteins to copy. In addition, due to gene silencing, gene replacement, and CRISPR/CAS9 technology, gene therapy methods have accelerated, and studies have been carried out to treat dominant and recessive mutations that cause genetic-induced hearing loss or increase hair cell regeneration. In this paper, potential gene therapy and stem cell applications in the acquisition of cochlear function, which causes sensorineural hearing loss, and the difficulties encountered in these applications are compiled from a bioengineering perspective.
Resting-State EEG Power and Machine-Learning Classification in Adult Males with Gambling Disorder
(Frontiers Media SA, 2026) Cinaroglu, Metin; Yilmazer, Eda; Ulker, Selami Varol; Tarlaci, Sultan
Background: Gambling disorder (GD) is a behavioral addiction sharing neurobiological features with substance use disorders, yet objective biomarkers remain limited. This study examined resting-state EEG power and applied machine learning to identify potential electrophysiological markers of GD. Methods: Resting eyes-closed Electroencephalography (EEG) was recorded from 47 individuals with GD and 32 healthy controls. Absolute and relative power across delta (1-4 Hz), theta (4-8 Hz), alpha (8-13 Hz), and beta (13-30 Hz) bands were quantified over eight cortical regions. Group differences and correlations with the South Oaks Gambling Screen (SOGS) were analyzed. Multiple comparisons were controlled using the Benjamini-Hochberg False Discovery Rate (FDR) correction. A Linear Discriminant Analysis (LDA) classifier was trained to differentiate GD from controls based on EEG features. Results: Group differences in EEG power were subtle, with GD showing significantly higher delta power in the left temporal region (p = 0.032, d = 0.43). Within the GD group, greater gambling severity was associated with higher absolute beta power across frontal, parietal, temporal, and occipital regions (r approximate to 0.40-0.50, p < 0.01), and these associations remained significant after FDR correction (pFDR < 0.05). The LDA model using absolute power achieved 73.7% classification accuracy (AUC = 0.74), whereas relative power yielded near-chance accuracy (57.9%). Conclusions: GD is characterized by subtle but meaningful EEG alterations, particularly increased beta activity linked to gambling severity. Multivariate EEG patterns can distinguish GD from controls, supporting the potential of resting-state EEG as a biomarker for clinical assessment and severity monitoring in behavioral addiction.
School-Based Psychosocial and Educational Interventions for Children and Adolescents After the 1999 Marmara Earthquakes in Turkey: A Review on Lessons Learned
(Pergamon-Elsevier Science Ltd, 2024) Cihanoglu, Mine; Vatansever, Merve; Erden, Gulsen
The massive earthquakes experienced in August and November 1999 affected thousands of people in the Marmara region, the most densely populated and industrialized part of Turkey. The humanitarian and economic cost was so enormous, and these earthquakes have changed the Turkish disaster management system and the Turkish people's approach to disasters. Marmara earthquakes are also considered as a milestone in the provision of psychosocial services for disaster victims. This paper aims to review the psychosocial interventions targeting children, adolescents, and their families after the 1999 earthquakes in Turkey. The progression from initial responses to more organized psychosocial interventions is outlined. Conducting the interventions at schools has ensured that thousands of children, teachers, and parents are reached in the most efficient and effective way possible. The significance of the school context in designing psychosocial interventions is highlighted and implications of the lessons learned for traumatic experiences of children and parents are also explored. It is evaluated that these inferences obtained from the Marmara earthquake in Turkey can be used in disasters around the world.

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