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Comparing Cognitive Behavioral Therapy and Ericksonian Hypnotherapy for Obsessive–Compulsive Disorder: A Randomized Controlled Trial
(Routledge, 2026) Çınaroğlu M.; Yılmazer E.; Odabaşı C.; Ülker S.V.; Tan S.; Hızlı Sayar G.
Obsessive–Compulsive Disorder (OCD) is a chronic condition that often responds well to Cognitive Behavioral Therapy (CBT), though many patients fail to achieve full remission. Ericksonian Hypnotherapy (EH) has been proposed as a promising alternative. This randomized controlled trial compared the efficacy of CBT and EH against a waitlist control in 99 adults with OCD. Participants received 12 weekly online therapy sessions. Outcomes were assessed at baseline, mid-treatment, and post-treatment using the Padua Inventory-Revised, Yale–Brown Obsessive Compulsive Scale–Self-Report (Y-BOCS-SR), and Beck Anxiety Inventory (BAI). Both CBT and EH led to large, statistically and clinically significant reductions in OCD symptoms compared to waitlist. CBT was more effective for compulsive behaviors such as washing, while EH produced greater reductions in obsessive rumination and general anxiety. No serious adverse events occurred. These findings suggest that EH is a viable and comparably effective treatment to CBT, with distinct therapeutic benefits. EH may offer a particularly useful option for patients with obsession-dominant symptom profiles or comorbid anxiety. © 2026 International Journal of Clinical and Experimental Hypnosis.
Comparison of Domino Transplantation with Two-Way Paired Exchange and Normal Transplantation: Acute Rejection, Surgical Complications, and 5-Year Survival Outcomes
(Springer, 2025) Huseynov, Amil; Cicek, Sevim Nuran Kuslu
Background Domino kidney paired donation and Two-Way Paired Exchange have emerged as vital strategies to expand the donor pool in renal transplantation, especially for patients facing ABO or HLA incompatibilities. Despite their potential benefits, concerns remain regarding immunological risks, infectious complications, and long-term graft survival. Methods In this retrospective cohort study conducted at Medicana Transplant Center, 980 adult kidney transplant recipients were categorized into three groups: Domino (n = 144), Two-Way Paired Exchange (n = 350), and Normal Transplant (n = 486). Baseline characteristics, acute rejection rates, and surgical or infectious complications were collected, alongside data on 1-year and 5-year patient and graft survival. Statistical analysis included Kaplan-Meier survival curves and Cox proportional hazards modeling for independent predictors of graft outcomes. Results The Domino group had the highest 1-year acute rejection rate (17.4%) compared to Two-Way Paired Exchange (4.3%) and Normal Transplant (3.7%), yet 1-year graft survival rates remained comparable (92%, 95%, and 96%, respectively; p = 0.271). Infectious complications were more frequent in the Domino group (25%) than in others (p < 0.01). Extended follow-up to 5 years indicated no statistically significant difference in overall graft or patient survival among the three groups (log-rank p = 0.197), despite a trend toward lower 5-year graft survival in the Domino group. Donor-specific antibodies and higher HLA mismatches independently predicted acute rejection. Conclusions Domino transplantation, while associated with higher immunologic challenges, achieves acceptable short-term and 5-year outcomes akin to Two-Way Paired Exchange and Normal Transplant. Careful immunosuppressive strategies, vigilant monitoring, and collaborative protocols are integral for optimizing long-term success in high-risk transplant scenarios.
The Development and Validation of an Integrated Assessment of Irrational Beliefs Concerning Basic Psychological Needs: The Rational Emotive Self-Determination Scale for Workers
(Frontiers Media Sa, 2025) Artiran, Murat; Tinaz, Pinar; Simsek, Omer Faruk; Miller, Anthony; Vione, Katia Correa; Turner, Martin James
Introduction Recently a new approach to understanding human behaviour has emerged that integrates rational emotive behaviour therapy (REBT) from the cognitive behavioural tradition, and self-determination theory (SDT) from the humanistic tradition. In the current study, we develop a psychometric that conceptualizes this new approach in organisational settings; the rational emotive self-determination scale for work (RESD-W). The RESD-W assesses respondents' irrational beliefs (from REBT) concerning the basic psychological needs (from SDT), namely perceptions of autonomy, competence, and relatedness within their work life. The RESD-W builds on initial validations of the RESD in adolescent populations (RESD-A).Methods In the current paper, the psychometric properties of the 16-item RESD-W were examined across five studies, in which the factor structure, the reliability of the scale, and construct and criterion-oriented validity of the RESD-W were assessed.Results Analyses confirmed theoretical expectations and yielded good psychometric properties. Scores in the RESD-W were associated with anxiety and depression, and negative emotions in the workplace.Discussion The results are discussed regarding practice, highlighting that work related psychological wellbeing may be predicated on the integration of irrational beliefs and basic psychological needs.
Digital Detox: Exploring the Impact of Cybersecurity Fatigue on Employee Productivity and Mental Health
(Springer Nature, 2025) Mizrak, Filiz; Demirel, Hatice Gokce; Yasar, Okan; Karakaya, Turhan
This study investigates the growing phenomenon of cybersecurity fatigue and its implications for employee productivity and mental health in the high-demand sectors of information technology (IT), finance, healthcare and education. Utilizing a quantitative research methodology, the study surveyed 351 employees from these industries to analyze the relationships between cybersecurity fatigue, work efficiency, and mental health indicators, including stress and anxiety. The findings highlight cybersecurity fatigue as a significant factor contributing to burnout, reduced productivity, and increased psychological strain. Structural Equation Modeling (SEM) demonstrates the moderating effects of digital detox initiatives and mental health support strategies in mitigating fatigue and improving employee well-being and organizational performance. This research addresses a critical gap by focusing on the human dimensions of cybersecurity management and offers practical recommendations for simplifying protocols and fostering resilience. The study provides actionable insights for organizations operating under stringent cybersecurity requirements, enabling them to enhance employee satisfaction and performance.
Discriminant Analysis Using MRI Asymmetry Indices and Cognitive Scores of Women with Temporal Lobe Epilepsy or Schizophrenia
(Springer Science and Business Media Deutschland GmbH, 2024) Fırat, Z.; Er, F.; Noyan, H.; Ekinci, G.; Üçok, A.; Ulǔg, A.M.; Aktekin, B.
Purpose: This study aims to assess the diagnostic power of brain asymmetry indices and neuropsychological tests for differentiating mesial temporal lobe epilepsy (MTLE) and schizophrenia (SCZ). Methods: We studied a total of 39 women including 13 MTLE, 13 SCZ, and 13 healthy individuals (HC). A neuropsychological test battery (NPT) was administered and scored by an experienced neuropsychologist, and NeuroQuant (CorTechs Labs Inc., San Diego, California) software was used to calculate brain asymmetry indices (ASI) for 71 different anatomical regions of all participants based on their 3D T1 MR imaging scans. Results: Asymmetry indices measured from 10 regions showed statistically significant differences between the three groups. In this study, a multi-class linear discriminant analysis (LDA) model was built based on a total of fifteen variables composed of the most five significantly informative NPT scores and ten significant asymmetry indices, and the model achieved an accuracy of 87.2%. In pairwise classification, the accuracy for distinguishing MTLE from either SCZ or HC was 94.8%, while the accuracy for distinguishing SCZ from either MTLE or HC was 92.3%. Conclusion: The ability to differentiate MTLE from SCZ using neuroradiological and neuropsychological biomarkers, even within a limited patient cohort, could make a substantial contribution to research in larger patient groups using different machine learning techniques. © The Author(s), under exclusive licence to Springer-Verlag GmbH Germany, part of Springer Nature 2024.
Effect of Multi-Artery Renal Grafts on Patient Outcomes in Living Donor Kidney Transplantation
(Springer, 2025) Huseynov, Amil; Sengul, Halil
BackgroundMultiple renal arteries (MRA) in a donor kidney can increase surgical complexity in living donor kidney transplantation. However, the impact of MRA on early transplant outcomes, including delayed graft function (DGF) and early graft failure, remains unclear.MethodsWe performed a single-center retrospective cohort study of 1,200 living donor kidney transplants conducted between 2019 and 2024. Donor kidneys were classified as having a single renal artery or multiple renal arteries (two or more). Recipient and donor characteristics, intraoperative details (ischemia times, vascular anastomosis technique), and postoperative outcomes (delayed graft function [DGF], primary nonfunction, and graft survival) were compared between the two groups. Logistic regression analyses were used to examine associations between MRA and the risk of DGF or graft failure within the first 90 days, both before and after adjusting for prespecified covariates.ResultsOf the 1,200 transplanted kidneys, 882 (73.5%) had a single artery and 318 (26.5%) had multiple arteries. Although the median cold-ischemia time was longer for multi-artery grafts (35.2 min vs. 29.4 min, p = 0.004), there were no significant differences in donor or recipient baseline characteristics. Multivariable logistic regression revealed no significant association between MRA and either DGF or early graft loss. Kaplan-Meier curves, censored for death, demonstrated similar graft survival in both groups (log-rank p = 0.25).ConclusionsIn this single-center cohort of living donor kidney transplants, grafts with multiple renal arteries did not exhibit an elevated risk of DGF or early graft loss. While additional surgical complexity is often required for MRA grafts, our findings suggest that these kidneys remain a safe and effective option for transplantation, supporting their broader use to expand the donor pool.
Effects of Ericksonian Hypnotherapy Versus Cognitive Behavioral Therapy on Prolonged Grief Among University Students: A Randomized Clinical Trial
(Routledge Journals, Taylor & Francis Ltd, 2025) Cinaroglu, Metin; Yilmazer, Eda; Ulker, Selami Varol; Cinar, Fadime
This study evaluates the comparative effectiveness of Ericksonian Hypnotherapy (EH) and Cognitive Behavioral Therapy (CBT) in addressing prolonged grief among university students in Istanbul. Transitioning through critical developmental phases, 39 students who had experienced significant loss and demonstrated symptoms of prolonged grief participated in this randomized controlled trial. They were divided equally into three groups: those receiving EH, those undergoing CBT, and a control group placed on a waiting list. Assessments utilized the Prolonged Grief Scale and the Beck Depression Inventory to measure the interventions' impact on grief. Findings revealed significant improvements in both EH and CBT groups compared to the control, with EH showing marginally higher effectiveness in reducing grief symptoms. This research underlines EH's potential as a culturally adaptable and effective treatment for prolonged grief in a diverse academic setting, advocating for its broader application and further exploration across various populations.
Efficacy of Cognitive-Behavioral Therapy in Reducing Muscle Dysmorphia Symptoms Among Turkish Gym Goers: A Pilot Study
(Elsevier, 2024) Cinaroglu, Metin; Yilmazer, Eda; Ulker, Selami Varol; Ahlatcioglu, Esra Noyan; Sayar, Gokben Hizli
Muscle dysmorphia (MD) is a disorder marked by an obsessive focus on muscularity, often leading to excessive exercise, rigid dieting, and use of performance-enhancing drugs (PEDs). While Cognitive-Behavioral Therapy (CBT) is known to be effective for various body image disorders, its specific effects on individuals with MD have been less studied. This qualitative case series involved seven male participants, aged 35-55, all diagnosed with MD and with a history of anabolic steroid use, undergoing a 12-week manualized CBT intervention. The study aimed to explore how CBT impacts their body image perceptions, exercise behaviors, steroid use, and emotional responses. Data were collected through participant feedback during therapy sessions, with thematic analysis revealing significant shifts in body image perception and reductions in compulsive behaviors and steroid use. Despite these improvements, participants experienced feelings of loss and anxiety as they modified their routines, and some reported relapses under stress, indicating the chronic nature of MD. The findings suggest that CBT effectively reshapes cognitive and behavioral patterns in MD sufferers but also highlight the need for ongoing support to manage the disorder's emotional complexities and prevent relapses. Future research should focus on long-term and individualized therapeutic approaches to better support those with muscle dysmorphia.
In Vitro Determination of Antileshmanial Activities of Benzimidazolium Derivatives on L. Major Promastigotes and Amastigotes
(Springer Int Publ Ag, 2023) Kelleci, Kubra; Golebatmaz, Eda
Purpose Leishmaniasis is a serious public health problem infecting millions of people worldwide. An effective and reliable treatment method to be used in the treatment of the disease has not been developed yet. Methods In this article, the anti-leishmanial activities of two benzimidazolium derivatives (B.A and B.B) against Leishmania major promastigotes and amastigotes, which are known to cause cutaneous leishmaniasis, were investigated for the first time. The immunostimulatory activity of the developed formulations was determined using the J774 murine macrophage cell line. Results B.A and B.B compounds were found to have a much higher cytotoxic effect than Amphotericin B (IC50 value 0.75 mu M +/- 0.03), which is used as the reference drug. The IC50 value was determined as 2.02 mu M +/- 0.52 for B.A and 1.83 mu M +/- 0.71 for B.B in Leishmania promastigotes. In addition, IC50 values of B. A and B.B Leishmania amastigotes were found to be 1.01 mu M and 0.67 mu M, respectively. It was found that B.B was 81.12 times more selective than Amphotericin B and showed the highest selectivity against L. major promastigotes (359.09) and amastigotes (980.80). Considering the selectivity indices (SI) of B.A and B.B, both compounds tested are more promising than Amphotericin B. Conclusion The results showed that benzimidazolium derivatives have anti-leishmanial potential against L. major, which is the causative agent of cutaneous leishmaniasis. Thus, we can say that the obtained results will help the development of effective and safe antileishmanial drug formulations against cutaneous leishmaniasis.
Interhemispheric EEG Coherence as a Candidate Biomarker in Gambling Disorder: Evidence of Frontal Hyperconnectivity and Posterior Disconnectivity
(Frontiers Media SA, 2025) Yilmazer, Eda; Cinaroglu, Metin; Ulker, Selami Varol; Tarlaci, Sultan
Background Gambling Disorder (GD) is a behavioral addiction marked by impaired decision-making and poor impulse control. We investigated whether resting-state interhemispheric quantitative EEG (qEEG) coherence-a measure of functional connectivity between homologous cortical regions-could serve as a biomarker of GD.Methods Twenty-nine male patients with GD and 45 healthy male controls underwent resting-state qEEG recording. Coherence was computed for homologous electrode pairs across delta, theta, alpha, and beta bands. Group differences were analyzed using independent-samples t-tests; associations with disorder duration were assessed via age-controlled partial correlations.Results Consistent with our hypothesis, GD participants exhibited frontal pole hypercoherence (Fp1-Fp2) across delta, theta, and beta bands, which is likely influenced by prefrontal/orbitofrontal generators. In contrast, GD showed hypocoherence in temporal (T3-T4, T5-T6), central (C3-C4), and parietal (P3-P4) regions across these frequencies. Greater disorder duration was associated with lower beta coherence at F3-F4 and Fp1-Fp2, and higher delta coherence at O1-O2.Conclusions These findings reveal a dual pattern of interhemispheric connectivity disruption in GD-hypercoherence at frontal pole sites and hypocoherence in sensorimotor and attentional posterior networks-supporting theoretical models of addiction neurocircuitry. Resting-state qEEG coherence holds promise as a clinically relevant biomarker for GD and may inform the development of neuromodulatory interventions aimed at network rebalancing.
Measuring Remote Working Skills: Scale Development and Validation Study
(Public Library of Science, 2024) Benligiray, Serap; Gungor, Abdullah Y.; Akbas, Ilkay
Remote work, one of the most significant working arrangements of today, requires certain employee skills. Although there are some hints, there is not much information in the literature on this subject. This study aims to identify the skills required for productive remote working activities and to develop a scale for measuring these skills. For this purpose, a thorough review of the literature, consultation with experts, and analysis of data obtained from four samples with remote working experience were all conducted. Within this context, item generation and content validation, initial factor structure analysis, and factor structure confirmation and construct validity examination were performed. Consequently, the Remote Working Skills Scale was developed, which has 36 items and five dimensions (cybersecurity, problem-solving, time management, verbal communication, and written communication).
Multimodal Neurophysiological Responses to Body Image Stimuli in Men with Muscle Dysmorphia and Steroid Use
(Elsevier, 2025) Cinaroglu, Metin; Yilmazer, Eda; Ulker, Selami Varol; Sayar, Gokben Hizli
Muscle dysmorphia (MD), a subtype of body dysmorphic disorder (BDD), involves a pathological preoccupation with muscularity and is commonly linked to anabolic steroid and performance-enhancing drugs (PEDs) use. Despite its rising prevalence, the neurophysiological and affective mechanisms underlying MD, particularly in steroid users, remain underexplored. This study examined 71 male strength-training participants (35 with BDD/ steroid use; 36 controls) during a passive viewing task of muscular, average, and slender male physiques while recording electroencephalography (EEG), electrodermal activity (EDA), and eye-tracking data. Psychometric assessments captured muscularity concerns (Muscle Dysmorphic Disorder Inventory, MDDI), anxiety (State-Trait Anxiety Inventory, STAI), obsessive-compulsive symptoms (Obsessive-Compulsive Inventory-Revised, OCI-R), appearance-related anxiety (Social Appearance Anxiety Scale, SAAS; Social Physique Anxiety Scale, SPAS), and selfesteem (Self-Liking/Self-Competence Scale-Revised, SLCS-R). The BDD/MD group showed significantly heightened responses to muscular stimuli across all modalities. EEG results revealed increased P300 and late positive potential (LPP) amplitudes, along with greater left-lateralized frontal alpha asymmetry. Eye-tracking indicated longer fixation durations and more frequent fixations on muscular images. EDA results showed elevated levels of autonomic arousal. Between-group differences in psychometric measures were substantial, with large effect sizes. Correlational analyses demonstrated significant associations between MD severity and neurophysiological markers, including LPP amplitude, frontal asymmetry, and EDA reactivity. These findings suggest that men with MD and steroid/PEDs use exhibit amplified attentional, emotional, and physiological reactivity to muscular body images. The integration of EEG, EDA, and eye-tracking provides novel insights into the neurocognitive-affective profile of BDD/MD, emphasizing the salience of idealized physiques in this population. Results support the potential utility of multimodal measures as objective indicators for assessing body image disturbance and underscore the need for targeted interventions addressing perceptual and emotional dysregulation in BDD/MD.
Of the Manuscript: Predictive Value of Renal Parenchyma and Pelvic Urine Density on Preoperative Non-Contrast CT in Systemic Inflammatory Response Syndrome (SIRS) After Semi-Rigid Ureteroscopy
(Springer, 2025) Ozsoy, Emrah; Kutluhan, Musab Ali; Tokuc, Emre; Kayar, Ridvan; Demir, Samet; Meric, Kaan; Ozturk, Metin Ishak
To evaluate the predictive value of preoperative NCCT (Non-Contrast Computed Tomography) measured renal parenchyma and pelvic urine densities for the development of systemic inflammatory response syndrome (SIRS) following URS. 1262 patients underwent semi-rigid URS due to ureterolithiasis between January 2008 and August 2023 were screened and 286 patients were included. Patient demographics and NCCT findings (stone size, location, density, hydronephrosis, renal parenchymal density, pelvic urine density) were collected retrospectively. Patients were categorized into two groups based on SIRS development after URS. Pelvic urine and parenchyma densities of the obstructed kidney were compared. A multivariate logistic regression analysis was performed to identify independent predictors of SIRS. The median obstructed kidney cortex mean density was significantly lower in the SIRS (+) group compared to the SIRS (-) group (26.67 [22.33-29.50] vs. 33.33 [27.24-37.75]). Obstructed kidney medulla mean density was also significantly lower in patients with SIRS (24.00 [22.33-27.50] vs. 31.50 [26.24-36.75], p = 0.001). Pelvic urine density was significantly higher in the SIRS-positive group. Stone density (OR = 1.35, % 95 CI: 1.09-1.67, p = 0.006), proximal ureteral location (OR = 5.21, % 95 CI: 1.84-14.7, p = 0.002), cortex mean density (OR = 0.91, % 95 CI: 0.87-0.95, p = 0.001) and pelvic urine density (OR = 1.07, % 95 CI: 1.02-1.12, p = 0.010) were stated as significant predictors. Renal parenchyma and pelvic urine density on pre-operative NCCT can predict SIRS after semi-rigid URS.
Opportunities and Challenges of Asynchronous Video Interviews: Perceptions of Human Resources Professionals from Türkiye
(Public Library of Science, 2025) Ilhan, Umit Deniz; Guler, Burcu Kumbul; Turgut, Dilara; Duran, Cem
In the context of global technological advancements, asynchronous video interviews (AVIs) have emerged as an innovative tool in recruitment, offering potential to transform traditional hiring practices. This study aims to enhance understanding of the opportunities and challenges associated with AVIs in recruitment processes by examining the perspectives of human resources (HR) professionals in T & uuml;rkiye. A qualitative research methodology with a phenomenological approach was employed. 15 HR professionals experienced in asynchronous video interviewing from diverse organizations participated in online, open-ended, semi-structured, in-depth interviews. The collected data were analyzed through thematic analysis using MAXQDA 2024. Findings indicated that AVIs offer significant opportunities, such as improving process efficiency, enhancing candidate experience, promoting fairness and inclusivity, and supporting organizational goals. However, the study identified critical challenges, including diminishing candidate experience, undermining fairness and increasing deceptive impression management, reducing job satisfaction among HR professionals, and imposing operational and financial constraints. As one of the first studies to explore HR professionals' perceptions of AVIs in T & uuml;rkiye, this study provides valuable insights into their adoption in developing economies and highlights the broader implications of AVIs in the global recruitment practices. The findings emphasize the need for tailored strategies to maximize benefits, address challenges, and balance the needs of both candidates and HR professionals.
Predictive Value of Renal Parenchyma and Pelvic Urine Density on Preoperative Non-Contrast CT in Systemic Inflammatory Response Syndrome (SIRS) After Semi-Rigid Ureteroscopy (Vol 54, 15, 2025)
(Springer, 2026) Ozsoy, Emrah; Kutluhan, Musab Ali; Tokuc, Emre; Kayar, Ridvan; Demir, Samet; Meric, Kaan; Ozturk, Metin Ishak
Psychological Correlates of Performance-Enhancing Drug Use: Emotional, Cognitive, and Social Functioning in Long-Term and Short-Term Users
(Frontiers Media SA, 2025) Cinaroglu, Metin; Yilmazer, Eda
Introduction Performance-enhancing drug (PED) use-particularly anabolic-androgenic steroids (AAS)-has expanded from competitive sport into mainstream fitness settings. Although PED use is associated with emotional, cognitive, and social difficulties, less is known about how duration of use or psychosocial factors shape these outcomes. Understanding these dynamics is essential for identifying individuals at greater risk for psychological impairment.Methods A total of 285 adult gym-goers (87 long-term users, 95 short-term users, 103 non-users) completed validated measures of depression (BDI-II), anxiety (BAI), muscle dysmorphia (MDDI), self-efficacy (GSE), social support (MSPSS), and social functioning (SASS), along with the Stroop test assessing executive function. Group comparisons, multiple regressions, and PROCESS-based mediation and moderation analyses were conducted, controlling for demographic covariates.Results Long-term PED users reported significantly higher depression, anxiety, and muscle dysmorphia than short-term users and non-users, and showed poorer Stroop interference performance. Mediation analysis revealed that depression and anxiety partially explained the link between PED use and poorer social functioning. Moderation results indicated that stronger self-efficacy and higher perceived social support buffered depressive and anxious symptoms among users.Discussion Chronic PED use is associated with heightened emotional distress and reduced executive functioning, which in turn contribute to impaired social functioning. However, psychosocial resources such as self-efficacy and social support may mitigate these adverse effects. These findings underscore the need for routine psychological assessment and the development of supportive, prevention-oriented interventions for individuals engaged in PED use.
Resting-State EEG Power and Machine-Learning Classification in Adult Males with Gambling Disorder
(Frontiers Media SA, 2026) Cinaroglu, Metin; Yilmazer, Eda; Ulker, Selami Varol; Tarlaci, Sultan
Background: Gambling disorder (GD) is a behavioral addiction sharing neurobiological features with substance use disorders, yet objective biomarkers remain limited. This study examined resting-state EEG power and applied machine learning to identify potential electrophysiological markers of GD. Methods: Resting eyes-closed Electroencephalography (EEG) was recorded from 47 individuals with GD and 32 healthy controls. Absolute and relative power across delta (1-4 Hz), theta (4-8 Hz), alpha (8-13 Hz), and beta (13-30 Hz) bands were quantified over eight cortical regions. Group differences and correlations with the South Oaks Gambling Screen (SOGS) were analyzed. Multiple comparisons were controlled using the Benjamini-Hochberg False Discovery Rate (FDR) correction. A Linear Discriminant Analysis (LDA) classifier was trained to differentiate GD from controls based on EEG features. Results: Group differences in EEG power were subtle, with GD showing significantly higher delta power in the left temporal region (p = 0.032, d = 0.43). Within the GD group, greater gambling severity was associated with higher absolute beta power across frontal, parietal, temporal, and occipital regions (r approximate to 0.40-0.50, p < 0.01), and these associations remained significant after FDR correction (pFDR < 0.05). The LDA model using absolute power achieved 73.7% classification accuracy (AUC = 0.74), whereas relative power yielded near-chance accuracy (57.9%). Conclusions: GD is characterized by subtle but meaningful EEG alterations, particularly increased beta activity linked to gambling severity. Multivariate EEG patterns can distinguish GD from controls, supporting the potential of resting-state EEG as a biomarker for clinical assessment and severity monitoring in behavioral addiction.
Volumetric and Cortical Thickness Alterations in Alcohol Dependence: Evidence of Accelerated Brain Aging and Clinical Correlations
(Frontiers Media SA, 2025) Cinaroglu, Metin; Yilmazer, Eda; Ulker, Selami Varol; Tacyildiz, Kerime; Tarlaci, Sultan
Background: Chronic alcohol dependence is associated with structural brain changes that resemble premature aging, particularly in frontal, parietal, and subcortical regions. This study examined brain volume, cortical thickness, and brain-predicted age in individuals with alcohol dependence and assessed associations with clinical symptoms. Methods: Thirty-one alcohol-dependent patients (mean age = 37.8 +/- 7.3 years) and 26 age-matched healthy controls (mean age = 35.0 +/- 8.5 years) underwent high-resolution T1-weighted MRI scanning. Brain structural analyses, including regional volumetry and cortical thickness estimation, were conducted using the validated volBrain platform. The system also provided individualized brain-predicted age estimates via its machine learning-based Brain Structure Ages (BSA) pipeline. Clinical assessments included the Michigan Alcoholism Screening Test (MATT), Penn Alcohol Craving Scale (PENN), Beck Depression and Anxiety Inventories (BDI-II, BAI), and detailed alcohol use history. Results: Alcohol-dependent participants showed significant reductions in total white matter, right frontal lobe, inferior frontal gyrus, bilateral postcentral gyri, and left superior occipital gyrus volumes (p < 0.05), along with widespread cortical thinning. Brain-predicted age was on average 11.5 years greater in patients than in controls (p < 0.001), especially in white matter and basal ganglia structures. Higher MATT scores correlated with reduced right precentral gyrus and left caudate volumes. PENN scores were positively associated with occipital volumes; however, this association weakened after controlling for age. Depression was linked to reduced frontal pole and increased amygdala volume, while anxiety was associated with smaller orbitofrontal and angular gyrus volumes. Conclusions: Alcohol dependence is marked by diffuse brain atrophy and accelerated brain aging. Structural alterations correspond to addiction severity, craving, and mood symptoms, highlighting brain-predicted age as a potential biomarker of cumulative alcohol-related neurodegeneration.

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