Investigation of Dpyd, Mthfr and Tyms Polymorphisms on 5-Fluorouracil Related Toxicities in Colorectal Cancer
| dc.contributor.author | Cevik, M. | |
| dc.contributor.author | Namal, E. | |
| dc.contributor.author | Şener, N.D. | |
| dc.contributor.author | Köksal, U.I. | |
| dc.contributor.author | Çaǧatay, P. | |
| dc.contributor.author | Deliorman, G. | |
| dc.contributor.author | Çiftçi, C. | |
| dc.contributor.author | Susleyici, Belgin | |
| dc.date.accessioned | 2026-01-30T14:56:08Z | |
| dc.date.available | 2026-01-30T14:56:08Z | |
| dc.date.issued | 2022 | |
| dc.description.abstract | Aim: To investigate the association of DPYD, MTHFR and TYMS polymorphisms on 5-fluorouracil (5-FU) related toxicities and patient survival. Materials & methods: A total of 103 colorectal cancer patients prescribed 5-FU were included in the study. Genotyping was conducted for several DPYD, MTHFR and TYMS polymorphisms using a microarray analyzer. Results: DPYD 496A>G polymorphism was found to be significantly associated with 5-FU related grade 0-2, but not severe toxicities (p = 0.02). Furthermore, patients with DPYD 85TC and CC genotypes had longer progression and overall survival times compared to TT genotypes in our study group (log rank = 6.60; p = 0.01 and log rank = 4.40; p = 0.04, respectively). Conclusion: According to our results, DPYD 496AG and GG genotypes might be protective against severe adverse events compared to the AA genotype. Another DPYD polymorphism, 85T>C, may be useful in colorectal cancer prognosis. Further studies for both polymorphisms should be conducted in larger populations to achieve accurate results. © 2022 Future Medicine Ltd. | en_US |
| dc.description.sponsorship | This study was supported by Marmara University Scientific Research Projects Coordination Unit. Project no: FEN-C-DRP-110718-0407. The authors have no other relevant affiliations or financial involvement with any organization or entity with a financial interest in or financial conflict with the subject matter or materials discussed in the manuscript apart from those disclosed. | |
| dc.description.sponsorship | Marmara Üniversitesi, (FEN-C-DRP-110718-0407) | |
| dc.identifier.doi | 10.2217/pme-2021-0047 | |
| dc.identifier.issn | 1741-0541 | |
| dc.identifier.issn | 1741-0541 | |
| dc.identifier.scopus | 2-s2.0-85138447228 | |
| dc.identifier.uri | https://doi.org/10.2217/pme-2021-0047 | |
| dc.identifier.uri | https://acikerisim2.beykoz.edu.tr/handle/123456789/248 | |
| dc.language.iso | en | en_US |
| dc.publisher | Newlands Press Ltd | en_US |
| dc.relation.ispartof | Personalized Medicine | en_US |
| dc.rights | info:eu-repo/semantics/closedAccess | en_US |
| dc.subject | Adverse Effects | en_US |
| dc.subject | Colorectal Cancer | en_US |
| dc.subject | DPYD | en_US |
| dc.subject | Fluoropyrimidines | en_US |
| dc.subject | MTHFR | en_US |
| dc.subject | Pharmacogenetics | en_US |
| dc.subject | Polymorphisms | en_US |
| dc.subject | TYMS | en_US |
| dc.title | Investigation of Dpyd, Mthfr and Tyms Polymorphisms on 5-Fluorouracil Related Toxicities in Colorectal Cancer | en_US |
| dc.type | Article | en_US |
| dspace.entity.type | Publication | |
| gdc.author.scopusid | 57216620714 | |
| gdc.author.scopusid | 36667213900 | |
| gdc.author.scopusid | 55555100000 | |
| gdc.author.scopusid | 56123720900 | |
| gdc.author.scopusid | 6507755715 | |
| gdc.author.scopusid | 57216614327 | |
| gdc.author.scopusid | 6602210835 | |
| gdc.author.scopusid | 6602894847 | |
| gdc.coar.access | metadata only access | |
| gdc.coar.type | text::journal::journal article | |
| gdc.description.department | Beykoz University | en_US |
| gdc.description.departmenttemp | [Cevik] Mehtap, Department of Molecular Biology, Marmara Üniversitesi, Istanbul, Turkey; [Namal] Esat, Department of Medical Oncology, Demiroglu Bilim University, Istanbul, Turkey; [Şener] Nur Dinc, Department of Medical Oncology, Demiroglu Bilim University, Istanbul, Turkey; [Köksal] Ülkühan Iner, Bağcilar Eğitim ve Araştirma Hastanesi, Istanbul, Turkey; [Çaǧatay] Penbe, Department of Medical Services and Techniques, Istanbul University-Cerrahpasa, Istanbul, Turkey; [Deliorman] Gokce, Department of Software Engineering, Beykoz Üniversitesi, Istanbul, Turkey; [Çiftçi] Çavlan, Department of Cardiology, Demiroglu Bilim University, Istanbul, Turkey; [Karaalp] Atila, Department of Medical Pharmacology, Marmara Üniversitesi Tip Fakültesi, Istanbul, Turkey; [Süsleyici] Belgin, Department of Molecular Biology, Marmara Üniversitesi, Istanbul, Turkey | en_US |
| gdc.description.endpage | 444 | en_US |
| gdc.description.issue | 5 | en_US |
| gdc.description.publicationcategory | Makale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı | en_US |
| gdc.description.scopusquality | Q4 | |
| gdc.description.startpage | 435 | en_US |
| gdc.description.volume | 19 | en_US |
| gdc.description.wosquality | Q3 | |
| gdc.identifier.pmid | 35880438 | |
| gdc.index.type | Scopus | |
| gdc.index.type | PubMed |