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Alterations in Niban Gene Expression as a Response to Stress Conditions in 3t3-L1 Adipocytes
(Springer, 2020) Cevik, Mehtap; Gunduz, Meliha Koldemir; Deliorman, Gokce; Susleyici, Belgin
Adipocyte death is important in obesity development. Understanding and prevention of adipocyte deaths may be a molecular approach in the treatment. In the study, we aimed to understand role of Niban gene, which acts as an anti-apoptotic molecule as a response to stress conditions, in adipocytes. 3T3-L1 adipocytes were treated with different doses of linoleic acid, hydrogen peroxide and ethanol; and proliferation of the cells examined with real time monitoring iCELLingence system. Gene expression levels were measured by q-PCR. As a response to 24h 480 mu M linoleic acid treatment, Niban gene expression was found to be higher than control group (p = 0.008), whereas 24 h 90 mM ethanol treatment was determined to be lower than control group (p = 0.008). The highest value of Niban gene expression among H2O2 treatment groups was detected in 4h 600 mu M H2O2 in comparison to control group (p = 0.008). To understand role of Niban in adipogenesis, Niban gene expressions were compared between pre-adipocytes and advanced fat accumulated adipocytes and determined to be significantly different (p = 0.042). Our results suggest that Niban might be involved in stress response process in adipocytes. However, the exact molecular role of Niban needs to be investigated in further studies.
Teneke Mahallesi in the Late Ottoman Capital: A Socio-Spatial Ground for the Co-Inhabitation of Roma Immigrants and the Local Poor
(Liverpool Univ Press, 2018) Yilgur, Egemen
The term teneke mahalle, literally "tin can neighbourhood," has been widely used since the Russo-Turkish War of 1877-1878 to describe a specific kind of urban fabrication, possibly poor and physically dilapidated, but also the sole, cheapest, and undoubtedly creative solution for the urgent housing needs of the poorest segments of the urban population. Even though these neighbourhoods were initially built at least partly by Muslim refugees, the Roma Mohadjirs,(1) teneke mahalles also welcomed other poor members of society seeking informal, easily accessible, and safe housing in late Ottoman Istanbul. This study discusses the role of the Roma in the formation of teneke mahalles, and the socio-historical dynamics that directed the non-Roma poor to co-inhabitation with Roma in these teneke mahalles, and outlines their socio-economic and cultural profile from various respects on the basis of the two oldest examples of this socio-spatial and perceptual phenomenon in Istanbul.
White-Matter Changes in Early and Late Stages of Mild Cognitive Impairment
(Elsevier Science Ltd, 2020) Femir-Gurtuna, Banu; Kurt, Elif; Ulasoglu-Yildiz, Cigdem; Bayram, Ali; Yildirim, Elif; Soncu-Buyukiscan, Ezgi; Bilgic, Basar
Mild Cognitive Impairment (MCI) is characterized by cognitive deficits that exceed age-related decline, but not interfering with daily living activities. Amnestic type of the disorder (aMCI) is known to have a high risk to progress to Alzheimer's Disease (AD), the most common type of dementia. Identification of very early structural changes in the brain related to the cognitive decline in MCI patients would further contribute to the understanding of the dementias. In the current study, we target to investigate whether the white-matter changes are related to structural changes, as well as the cognitive performance of MCI patients. Forty-nine MCI patients were classified as Early MCI (E-MCI, n = 24) and Late MCI (L-MCI, n = 25) due to their performance on The Free and Cued Selective Reminding Test (FCSRT). Age-Related White-Matter Changes (ARWMC) scale was used to evaluate the white-matter changes in the brain. Volumes of specific brain regions were calculated with the FreeSurfer program. Both group and correlation analyses were conducted to show if there was any association between white-matter hyperintensities (WMHs) and structural changes and cognitive performance. Our results indicate that, L-MCI patients had significantly more WMHs not in all but only in the frontal regions compared to E-MCI patients. Besides, ARWMC scores were not correlated with total hippocampal and white-matter volumes. It can be concluded that WMHs play an important role in MCI and cognitive functions are affected by white-matter changes of MCI patients, especially in the frontal regions. (C) 2020 Elsevier Ltd. All rights reserved.

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